metamorph software (MetaMorph Inc)
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Metamorph Software, supplied by MetaMorph Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/software+metamorph/metamorph+software/pmc12182373-62-0-20
Average 90 stars, based on 1 article reviews
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1) Product Images from "RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation"
Article Title: RNA binding proteins PCBP1 and PCBP2 regulate pancreatic β cell translation
Journal: Molecular Metabolism
doi: 10.1016/j.molmet.2025.102175
Figure Legend Snippet: Ablating Pcbp1 in β cells upregulates PCBP2 and does not alter glucose homeostasis. (A) Model of Cre-mediated recombination of Pcbp1 . The top diagram represents the Pcbp1 locus (light boxes represent UTRs, dark box represents protein coding region, and arrow represents transcriptional start site) with inserted loxP sites (triangles). Bottom diagram represents the Pcbp1 locus following RIP-Cre mediated recombination and remaining loxP site (triangle). (B) Western blot showing PCBP1 levels in islets from 26 week old male Pcbp1 βKO mice ( Pcbp1 Fl/Fl ,n = 3; Pcbp1 βKO ,n = 3). (C) Co-immunofluorescence staining for PCBP1 and Insulin in adult islets from 7 week old male Pcbp1 Fl/Fl and Pcbp1 βKO mice (scale bar, 50 μm). (D) Intraperitoneal glucose tolerance tests performed on 8–11 week old male mice (n = 9 Pcbp1 Fl/Fl and n = 11 Pcbp1 βKO ). (E) Western blots showing PCBP2 levels in islets from 26 week old male Pcbp1 Fl/Fl and Pcbp1 βKO mice ( Pcbp1 Fl/Fl , n = 3; Pcbp1 βKO , n = 3). ∗P-value<0.05, ∗∗P-value<0.01 by student's t-test.
Techniques Used: Western Blot, Immunofluorescence, Staining
Figure Legend Snippet: Single cell RNA sequencing of Pcbp1 and Pcbp2 co-depleted β cells reveals dysregulation of a translational mRNA program. (A) Co-immunofluorescence staining for PCBP1 and PCBP2 in adult islets from 11–12 week old male Pcbp1/2 Fl/Fl and Pcbp1/2 βKO mice (scale bar, 50 μm). Yellow arrows denote PCBP1 and PCBP2 co-depleted β cells. (B) Merged uniform manifold approximation and projection (UMAP) plot showing 3,592 control β cells (red) and 1,554 Pcbp1/2 co-depleted β cells (blue). (C) UMAP plot showing identified β cell subclusters in control and mutant β cells. (D) Dotplot showing the relative expression of Ins1 , Pcbp1 , and Pcbp2 transcript levels in each identified β cell subcluster. (E) Volcano plot of genes with significantly downregulated (blue) and upregulated (red) transcript levels in cluster 11 as compared to control β cells. (F) Reactome pathway analysis of the genes with altered mRNA levels in the setting of Pcbp1/2 co-deficiency.
Techniques Used: RNA Sequencing, Immunofluorescence, Staining, Control, Mutagenesis, Expressing
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Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Western Blot:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Staining:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Immunohistochemistry:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Phospho-proteomics:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Immunostaining:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Immunohistochemical staining:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Saline:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Real-time Polymerase Chain Reaction:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Incubation:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Control:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Imaging:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the Cell Culture:Article Title: Synthesis and structure-activity relationship of boronic acid bioisosteres of combretastatin A-4 as anticancer agents. Article Snippet: Article Title: The in vivo blood compatibility of bio-inspired small diameter vascular graft: effect of submicron longitudinally aligned topography Article Snippet: With the help of software Article Title: Therapeutic Potential of Microbiota Modulation in Alzheimer’s Disease: A Review of Preclinical Studies Article Snippet: Following this, Article Title: Identification of a regulatory pathway of L-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells. Article Snippet: Glucagon like peptide-1 (GLP-1) is one of incretin hormone and is secreted when enteroendocrine L cells sense saccharides, amino acids, and fatty acids.. Some amino acids have been shown to promote GLP-1 secretion from small intestinal enteroendocrine L cells.. However, the molecular mechanisms that Lphenylalanine, a potent trigger of GLP-1 secretion, causes GLP-1 secretion from enteroendocrine L cells has not been elucidated. Article Title: NMDA receptor autoantibodies primarily impair the extrasynaptic compartment. Article Snippet: Article Title: Direct imaging and automatic analysis in tumor-on-chip reveal cooperative antitumoral activity of immune cells and oncolytic vaccinia virus. Article Snippet: Organ-on-chip and tumor-on-chip microfluidic cell cultures represent a fast-growing research field for modelling organ functions and diseases, for drug development, and for promising applications in personalized medicine.. Still, one of the bottlenecks of this technology is the analysis of the huge amount of bio-images acquired in these dynamic 3D microenvironments, a task that we propose to achieve by exploiting the interdisciplinary contributions of computer science and electronic engineering.. In this work, we apply this strategy to the study of oncolytic vaccinia virus (OVV), an emerging agent in cancer immunotherapy. Article Title: The ACE2 decoy receptor can overcome immune escape by rapid mutating SARS-CoV-2 variants and reduce cytokine induction and clot formation. Article Snippet: Fusion events were visualized using a Zeiss Axiovert 200 M Article Title: Targeted delivery of cytotoxic proteins to prostate cancer via conjugation to small molecule urea-based PSMA inhibitors Article Snippet: Cells were photographed using a Nikon TE200 fluorescence microscope with the |